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Induction of Sertoli-like cells from human fibroblasts by NR5A1 and GATA4

11 Nov 2019

Abstract excerpt

Sertoli cells are essential nurse cells in the testis that regulate the process of spermatogenesis and establish the immune-privileged environment of the blood-testis-barrier (BTB). Here, we report the in vitro reprogramming of fibroblasts to human induced Sertoli-like cells (hiSCs). Initially, five transcriptional factors and a gene reporter carrying the AMH promoter were utilized to obtain the hiSCs. We further...

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PMID: 31710289
DOI: 10.7554/elife.48767

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