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Article

Transplanted human p75-positive stem Leydig cells replace disrupted Leydig cells for testosterone production

12 Oct 2017

Abstract excerpt

Abstract Previous studies have demonstrated that rodent stem Leydig cell (SLC) transplantation can partially restore testosterone production in Leydig cell (LC)-disrupted or senescent animal models, which provides a promising approach for the treatment of hypogonadism. Here, we isolated human SLCs prospectively and explored the potential therapeutic benefits of human SLC transplantation for hypogonadism...

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PMID: 29022899
DOI: 10.1038/cddis.2017.531

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