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Stem Leydig Cells in the Adult Testis: Characterization, Regulation and Potential Applications

1 Nov 2019

Abstract excerpt

Androgen deficiency (hypogonadism) affects males of all ages. Testosterone replacement therapy (TRT) is effective in restoring serum testosterone and relieving symptoms. TRT, however, is reported to have possible adverse effects in part because administered testosterone is not produced in response to the hypothalamic-pituitary-gonadal (HPG) axis. Progress in stem cell biology offers potential alternatives for...

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PMID: 31673697
DOI: 10.1210/endrev/bnz013

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