Article
Evolutionary Pressures Shape Undifferentiated Pleomorphic Sarcoma Development and Radiotherapy Response.
Cancer research - 14 Mar 2025
Blomain Erik S, Soudi Shaghayegh, Wang Ziwei, Somani Anish, Subramanian Ajay, Nouth Serey C L, Oladipo Eniola, New Christin, Kenney Deborah E, Nemat-Gorgani Neda, Kindler Thomas, Avedian Raffi S, Steffner Robert J, Mohler David G, Hiniker Susan M, Chin Alexander L, Kalbasi Anusha, Binkley Michael S, Fried Marius, Gaida Matthias M, van de Rijn Matt, Moding Everett J
Abstract excerpt
Radiotherapy is an integral component in the treatment of many types of cancer, with approximately half of patients with cancer receiving radiotherapy. Systemic therapy applies pressure that can select for resistant tumor subpopulations, underscoring the importance of understanding how radiation impacts tumor evolution to improve treatment outcomes. We integrated temporal genomic profiling of 120 spatially...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.