Article

Ex vivo stem-like cell families model evolution of glioblastoma therapeutic resistance

2026-04-06

Abstract excerpt

Glioblastoma (GBM) arises from stem-like cells (GSCs) that exhibit intrinsic therapeutic resistance and can be positively selected by treatment, rendering recurrent GBM intractable. Mechanistic dissection of therapeutic resistance evolution has been limited by scarce matched primary/recurrent tractable models. To address this gap, we developed "resistant GSC families", a within-patient matched platform that models...

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Literature Corpus work: e038d4dc-63ac-5972-a9ed-147e039f4176
DOI: 10.64898/2026.04.02.716158

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