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Undifferentiated Sarcomas Develop through Distinct Evolutionary Pathways

1 Mar 2019

Abstract excerpt

Undifferentiated sarcomas (USARCs) of adults are diverse, rare, and aggressive soft tissue cancers. Recent sequencing efforts have confirmed that USARCs exhibit one of the highest burdens of structural aberrations across human cancer. Here, we sought to unravel the molecular basis of the structural complexity in USARCs by integrating DNA sequencing, ploidy analysis, gene expression, and methylation profiling. We...

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PMID: 30889380
DOI: 10.1016/j.ccell.2019.02.002

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