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Article

Genetic variants in COMT and ESR1 genes shape treatment response to raloxifene in schizophrenia-spectrum disorders.

Psychoneuroendocrinology - 1 Feb 2025

Brand Bodyl A, Boer Anne Jetske, de Boer Janna N, Bozaoglu Kiymet, Morris Kim, Rossell Susan, Sommer Iris E C

Abstract excerpt

BACKGROUND/OBJECTIVE: Raloxifene, a selective estrogen receptor modulator (SERM), may improve symptoms and cognition in schizophrenia spectrum disorders (SSD). Studies have shown inconsistent efficacy, especially in men with SSD. We assessed whether single nucleotide polymorphisms (SNPs) on genes involved in the pharmacodynamics (ESR1 and COMT) and pharmacokinetics (UGT1A8) of raloxifene can explain the...

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Share to Catechol O-Methyltransferase
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 39799793
DOI: 10.1016/j.psyneuen.2024.107274

Genes

COMT
ESR1
UGT1A8

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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