Article
Association of estrogen receptor alpha gene polymorphism with age at onset, general psychopathology symptoms, and therapeutic effect of schizophrenia.
Behavioral and brain functions : BBF - 15 Mar 2013
Wang Shuai, Li Wenqiang, Zhao Jingyuan, Zhang Hongxing, Yang Yongfeng, Wang Xiujuan, Yang Ge, Lv Luxian
Abstract excerpt
BACKGROUND: Estrogen is believed to play an important role in the central nervous system (CNS) and exert a protective role against schizophrenia. Estrogen receptor alpha (ESRα) mediates the biological action of estrogen. Rs2234693 and rs9340799, single nucleotide polymorphisms of ESRα, may be related to many psychiatric disorders, while their association with schizophrenia has not been clarified. METHODS:...
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