COMT and Neuregulin 1 Markers for Personalized Treatment of Schizophrenia Spectrum Disorders Treated with Risperidone Monotherapy.

doi:10.3390/biom14070777

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COMT and Neuregulin 1 Markers for Personalized Treatment of Schizophrenia Spectrum Disorders Treated with Risperidone Monotherapy.

Biomolecules - 29 Jun 2024

Bondrescu Mariana, Dehelean Liana, Farcas Simona Sorina, Papava Ion, Nicoras Vlad, Mager Dana Violeta, Grecescu Anca Eliza, Podaru Petre Adrian, Andreescu Nicoleta Ioana

Abstract excerpt

Pharmacogenetic markers are current targets for the personalized treatment of psychosis. Limited data exist on COMT and NRG1 polymorphisms in relation to risperidone treatment. This study focuses on the impact of COMT rs4680 and NRG1 (rs35753505, rs3924999) polymorphisms on risperidone treatment in schizophrenia spectrum disorders (SSDs). This study included 103 subjects with SSD treated with risperidone...

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Antipsychotic Agents

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Catechol O-Methyltransferase

Genotype

Neuregulin-1

Polymorphism, Single Nucleotide

Precision Medicine

Risperidone

Schizophrenia

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Open in PubMed Open full text

Identifiers

PMID: 39062492
DOI: 10.3390/biom14070777
PMCID: PMC11275090

Genes

COMT
NRG1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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