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Article

Molecular mechanisms underlying allosteric behavior of Escherichia coli DgoR, a GntR/FadR family transcriptional regulator.

Nucleic acids research - 7 Jan 2025

Singh Swati, Arya Garima, Mishra Rajesh, Singla Shivam, Pratap Akhil, Upadhayay Krishna, Sharma Monika, Chaba Rachna

Abstract excerpt

GntR/FadR family featuring an N-terminal winged helix-turn-helix DNA-binding domain and a C-terminal α-helical effector-binding and oligomerization domain constitutes one of the largest families of transcriptional regulators. Several GntR/FadR regulators govern the metabolism of sugar acids, carbon sources implicated in bacterial-host interactions. Although effectors are known for a few sugar acid regulators, the...

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PMID: 39777470
DOI: 10.1093/nar/gkae1299
PMCID: PMC11705089

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