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Article

Molecular insights into effector binding by DgoR, a GntR/FadR family transcriptional repressor of D-galactonate metabolism in Escherichia coli.

Molecular microbiology - 1 Apr 2021

Arya Garima, Pal Mohinder, Sharma Monika, Singh Bhupinder, Singh Swati, Agrawal Vishal, Chaba Rachna

Abstract excerpt

Several GntR/FadR transcriptional regulators govern sugar acid metabolism in bacteria. Although effectors have been identified for a few sugar acid regulators, the mode of effector binding is unknown. Even in the overall FadR subfamily, there are limited details on effector-regulator interactions. Here, we identified the effector-binding cavity in Escherichia coli DgoR, a FadR subfamily transcriptional repressor...

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PMID: 33068046
DOI: 10.1111/mmi.14625

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