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Article

Domain cross-talk during effector binding to the multidrug binding TTGR regulator.

The Journal of biological chemistry - 9 Jul 2010

Daniels Craig, Daddaoua Abdelali, Lu Duo, Zhang Xiaodong, Ramos Juan-Luis

Abstract excerpt

A major mechanism of antibiotic resistance in bacteria is the active extrusion of toxic compounds through membrane-bound efflux pumps. The TtgR protein represses transcription of ttgABC, a key efflux pump in Pseudomonas putida DOT-T1E capable of extruding antibiotics, solvents, and flavonoids. TtgR contains two distinct and overlapping ligand binding sites, one is broad and contains mainly hydrophobic residues,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 20435893
DOI: 10.1074/jbc.M110.113282
PMCID: PMC2898380

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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