Article
Role of the PFXFATG[G/Y] Motif in the Activation of SdrG, a Response Regulator Involved in the Alphaproteobacterial General Stress Response.
Structure (London, England : 1993) - 2 Aug 2016
Campagne Sébastien, Dintner Sebastian, Gottschlich Lisa, Thibault Maxence, Bortfeld-Miller Miriam, Kaczmarczyk Andreas, Francez-Charlot Anne, Allain Frédéric H-T, Vorholt Julia A
Abstract excerpt
Two-component systems are major signal transduction pathways, which consist of histidine kinases and response regulators that communicate through phosphorylation. Here, we highlight a distinct class of single-domain response regulators containing the PFXFATG[G/Y] motif that are activated by a mechanism distinct from the Y-T coupling described for prototypical receiver domains. We first solved the structures of...
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