Article
A new glimpse of FadR-DNA crosstalk revealed by deep dissection of the E. coli FadR regulatory protein.
Protein & cell - 1 Dec 2014
Zhang Yongchang, Gao Rongsui, Ye Huiyan, Wang Qingjing, Feng Youjun
Abstract excerpt
Escherichia coli (E. coli) FadR regulator plays dual roles in fatty acid metabolism, which not only represses the fatty acid degradation (fad) system, but also activates the unsaturated fatty acid synthesis pathway. Earlier structural and biochemical studies of FadR protein have provided insights into interplay between FadR protein with its DNA target and/or ligand, while the missing knowledge gap (esp. residues...
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