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Article

Sibling similarity can reveal key insights into genetic architecture.

eLife - 8 Jan 2025

Souaiaia Tade, Wu Hei Man, Hoggart Clive, O'Reilly Paul F

Abstract excerpt

The use of siblings to infer the factors influencing complex traits has been a cornerstone of quantitative genetics. Here, we utilise siblings for a novel application: the inference of genetic architecture, specifically that relating to individuals with extreme trait values (e.g. in the top 1%). Inferring the genetic architecture most relevant to this group of individuals is important because they are at the...

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PMID: 39773384
DOI: 10.7554/eLife.87522
PMCID: PMC11709432

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