Article

Sibling Similarity Can Reveal Key Insights Into Genetic Architecture

2023-02-21

Abstract excerpt

The use of siblings to infer the factors influencing complex traits has been a cornerstone of quantitative genetics. Here we utilise siblings for a novel application: the identification of genetic architecture, specifically that in individuals with extreme trait values (e.g. in the top 1%). Establishing genetic architecture in these individuals is important because they are at greatest risk of disease and are most...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 5a09d6fb-793c-5d3d-9851-ce84b2ce0eb3
DOI: 10.1101/2023.02.19.529159

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Sibling Similarity Can Reveal Key Insights Into Genetic ArchitectureDOI 10.1101/2023.02.19.529159Read

Sibling similarity can reveal key insights into genetic architecture.Semantic proximity Read

Sibling validation of polygenic risk scores and complex trait prediction.Semantic proximity Read

Striking Departures from Polygenic Architecture in the Tails of Complex TraitsSemantic proximity Read

Distinct genetic architecture in the tails of complex traits.Semantic proximity Read

Genetic architecture: the shape of the genetic contribution to human traits and disease.Semantic proximity Read

Within-Family Validation of Polygenic Risk Scores and Complex Trait PredictionSemantic proximity Read

From Genotype to Phenotype: Polygenic Prediction of Complex Human Traits.Semantic proximity Read

Sex differences in genetic architecture in the UK Biobank.Semantic proximity Read

Detecting Shared Genetic Architecture Among Multiple Phenotypes by Hierarchical Clustering of Gene-Level Association Statistics.Semantic proximity Read

Accurate detection of shared genetic architecture from GWAS summary statistics in the small-sample context.Semantic proximity Read

Sexual differences in genetic architecture in UK BiobankSemantic proximity Read

Simple scaling laws control the genetic architectures of human complex traitsSemantic proximity Read