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Article

Cardiac myosin-binding protein-C is a critical mediator of diastolic function.

Pflugers Archiv : European journal of physiology - 1 Mar 2014

Tong Carl W, Nair Nandini A, Doersch Karen M, Liu Yang, Rosas Paola C

Abstract excerpt

Diastolic dysfunction prominently contributes to heart failure with preserved ejection fraction (HFpEF). Owing partly to inadequate understanding, HFpEF does not have any effective treatments. Cardiac myosin-binding protein-C (cMyBP-C), a component of the thick filament of heart muscle that can modulate cross-bridge attachment/detachment cycling process by its phosphorylation status, appears to be involved in the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 24442121
DOI: 10.1007/s00424-014-1442-1
PMCID: PMC3928517

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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