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Article

Preserved cross-bridge kinetics in human hypertrophic cardiomyopathy patients with MYBPC3 mutations.

Pflugers Archiv : European journal of physiology - 1 Aug 2014

van Dijk Sabine J, Boontje Nicky M, Heymans Martijn W, Ten Cate Folkert J, Michels Michelle, Dos Remedios Cris, Dooijes Dennis, van Slegtenhorst Marjon A, van der Velden Jolanda, Stienen Ger J M

Abstract excerpt

Mutations in the MYBPC3 gene, encoding cardiac myosin binding protein C (cMyBP-C) are frequent causes of hypertrophic cardiomyopathy (HCM). Previously, we have presented evidence for reduced cMyBP-C expression (haploinsufficiency), in patients with a truncation mutation in MYBPC3. In mice, lacking cMyBP-C cross-bridge kinetics was accelerated. In this study, we investigated whether cross-bridge kinetics was...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 24186209
DOI: 10.1007/s00424-013-1391-0

Genes

MYBPC3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Preserved cross-bridge kinetics in human hypertrophic cardiomyopathy patients with MYBPC3 mutations.PMID 24186209Read ↗

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