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Article

Phosphorylation of cMyBP-C affects contractile mechanisms in a site-specific manner.

Biophysical journal - 4 Mar 2014

Wang Li, Ji Xiang, Barefield David, Sadayappan Sakthivel, Kawai Masakata

Abstract excerpt

Cardiac myosin binding protein-C (cMyBP-C) is a cardiac-specific, thick-filament regulatory protein that is differentially phosphorylated at Ser(273), Ser(282), and Ser(302) by various kinases and modulates contraction. In this study, phosphorylation-site-specific effects of cMyBP-C on myocardial contractility and cross-bridge kinetics were studied by sinusoidal analysis in papillary and trabecular muscle fibers...

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Identifiers

PMID: 24606935
DOI: 10.1016/j.bpj.2014.01.029
PMCID: PMC4026776

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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