Cardiac myosin-binding protein C: hypertrophic cardiomyopathy mutations and structure-function relationships.

doi:10.1007/s00424-013-1400-3

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Cardiac myosin-binding protein C: hypertrophic cardiomyopathy mutations and structure-function relationships.

Pflugers Archiv : European journal of physiology - 1 Feb 2014

Sequeira Vasco, Witjas-Paalberends E Rosalie, Kuster Diederik W D, van der Velden Jolanda

Abstract excerpt

Cardiac myosin-binding protein C (cMyBP-C) research has been characterized by two waves. Initial interest was piqued by its discovery in 1973 as a contaminant of myosin preparations from skeletal muscle. The second wave started in 1995 by the discovery that mutations in the gene encoding cMyBP-C cause hypertrophic cardiomyopathy (HCM). In this review, we will address what is known of cMyBP-C's role as a regulator...

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Cardiac myosin-binding protein C: hypertrophic cardiomyopathy mutations and structure-function relationships.

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Cardiac myosin-binding protein C: hypertrophic cardiomyopathy mutations and structure-function relationships.

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