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Article

Early-Onset Hypertrophic Cardiomyopathy Mutations Significantly Increase the Velocity, Force, and Actin-Activated ATPase Activity of Human β-Cardiac Myosin.

Cell reports - 13 Dec 2016

Adhikari Arjun S, Kooiker Kristina B, Sarkar Saswata S, Liu Chao, Bernstein Daniel, Spudich James A, Ruppel Kathleen M

Abstract excerpt

Hypertrophic cardiomyopathy (HCM) is a heritable cardiovascular disorder that affects 1 in 500 people. A significant percentage of HCM is attributed to mutations in β-cardiac myosin, the motor protein that powers ventricular contraction. This study reports how two early-onset HCM mutations, D239N and H251N, affect the molecular biomechanics of human β-cardiac myosin. We observed significant increases (20%-90%) in...

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Identifiers

PMID: 27974200
DOI: 10.1016/j.celrep.2016.11.040
PMCID: PMC11088367

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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