Article
The gain-of-function variant in the NLRP3 gene predicts the effectiveness of brief psychotherapy but not the risk of major depression.
Behavioural brain research - 12 Mar 2025
Ferreira Fabiana Barreiros, Kaufmann Fernanda Neutzling, Bastos Clarissa Ribeiro, Xavier Janaína, Aniszewski Stephanie, Molina Mariane Lopez, Lara Diogo Rizzato, Jansen Karen, da Silva Ricardo Azevedo, Souza Luciano Dias de Mattos, Kaster Manuella Pinto, Ghisleni Gabriele
Abstract excerpt
Major depressive disorder (MDD) is a highly prevalent psychiatric condition whose pathophysiology has been linked to neuroinflammatory processes involving the NLRP3 inflammasome. To address this point, the study investigated the association of the NLRP3 rs10754558 polymorphism with MDD diagnosis in a young adults population based study and the effectiveness of brief psychotherapies in a randomized clinical trial....
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