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Exploring the potential impact of TNF-α inhibition on major depressive disorder risk: Insights from a prospective cohort and genetic evidence.

Brain, behavior, and immunity - 1 Aug 2026

Chen Ming, Huang Haozhang, Huang Xinchengcheng, Liu Jin, Liu Yihui, Yu Qianting, Ruan Huangtao, Nguyen Sau Van, Lu Xiaozhao, Zheng Shuo, He Yibo, Liu Yong, Hou Cailan, Chen Shiqun

Abstract excerpt

BACKGROUND: A growing body of evidence suggests that inflammatory dysregulation contributes causally to major depressive disorder (MDD) in a subset of individuals. Tumour necrosis factor-α (TNF-α), a key cytokine linking peripheral inflammation and neural dysfunction, may represent a modifiable target for immunomodulatory intervention. OBJECTIVE: To evaluate whether genetically proxied for TNF-α inhibition...

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PMID: 41951112
DOI: 10.1016/j.bbi.2026.106589

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TNF
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