Article
Interaction between childhood maltreatment on immunogenetic risk in depression: Discovery and replication in clinical case-control samples.
Brain, behavior, and immunity - 1 Jan 2018
Cohen-Woods S, Fisher H L, Ahmetspahic D, Douroudis K, Stacey D, Hosang G M, Korszun A, Owen M, Craddock N, Arolt V, Dannlowski U, Breen G, Craig I W, Farmer A, Baune B T, Lewis C M, Uher R, McGuffin P
Abstract excerpt
Major depressive disorder (MDD) is a prevalent disorder with moderate heritability. Both MDD and interpersonal adversity, including childhood maltreatment, have been consistently associated with elevated inflammatory markers. We investigated interaction between exposure to childhood maltreatment and extensive genetic variation within the inflammation pathway (CRP, IL1b, IL-6, IL11, TNF, TNFR1, and TNFR2) in...
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