Association of the GRIK4 rs1954787 polymorphism with clinical response in antidepressant-treated depressed patients: results from a prospective cohort and meta-analysis.

doi:10.1038/s41380-024-02765-5

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Article

Association of the GRIK4 rs1954787 polymorphism with clinical response in antidepressant-treated depressed patients: results from a prospective cohort and meta-analysis.

Molecular psychiatry - 1 Apr 2025

Chappell Kenneth, Colle Romain, El Asmar Khalil, Gressier Florence, Bouligand Jérôme, Trabado Séverine, Fève Bruno, Becquemont Laurent, Corruble Emmanuelle, Verstuyft Céline

Abstract excerpt

Major Depressive Disorder (MDD) is the leading cause of disability worldwide. Genetic factors influence the effect of its main treatment option, antidepressant drugs (ATD). The GRIK4 rs1954787(T>C) genetic polymorphism was associated with response following 1-3 months of ATD treatment in some studies, but not others. We aimed to analyze its association with clinical outcomes in a cohort of 6-month ATD-treated...

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Topics

Humans
Antidepressive Agents
Major Depressive Disorder

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Male

Female

Middle Aged

Polymorphism, Single Nucleotide

Adult

Treatment Outcome

Kainic Acid Receptors

Prospective Studies

Alleles

Genotype

Cohort Studies

Source

Open in PubMed

Identifiers

PMID: 39462036
DOI: 10.1038/s41380-024-02765-5

Genes

GRIK4

Provenance

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