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Article

The role of pro-inflammatory cytokine gene polymorphisms in major depressive disorder: a systematic review.

Pharmacogenetics and genomics - 1 Sept 2026

Kalidasan Yuvapriya, Venkatesan Vettriselvi, Kantipudi Suvarna Jyothi, Ramachandran Ilangovan

Abstract excerpt

Major depressive disorder (MDD) is a multifactorial psychiatric disorder increasingly associated with immune-inflammatory mechanisms. Pro-inflammatory cytokines, particularly tumor necrosis factor-alpha (TNF-α) and interleukin-1 beta (IL-1β), have been implicated in the pathophysiology of MDD through their influence on neuroinflammation, neurotransmitter regulation, and hypothalamic-pituitary-adrenal (HPA) axis...

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Share to Cytokines
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 42307972
DOI: 10.1097/FPC.0000000000000609

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TNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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