Article
HMGA2 overexpression with specific chromosomal abnormalities predominate in CALR and ASXL1 mutated myelofibrosis.
Leukemia - 1 Mar 2025
Handa Shivani, Schaniel Christoph, Tripodi Joseph, Ahire Daiva, Mia Md Babu, Klingborg Sophie, Tremblay Douglas, Marcellino Bridget K, Hoffman Ronald, Najfeld Vesna
Abstract excerpt
Although multiple genetic events are thought to play a role in promoting progression of the myeloproliferative neoplasms (MPN), the individual events that are associated with the development of more aggressive disease phenotypes remain poorly defined. Here, we report that novel genomic deletions at chromosome 12q14.3, as detected by a high-resolution array comparative genomic hybridization plus single nucleotide...
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