Article
Epigenetic abnormalities in myeloproliferative neoplasms: a target for novel therapeutic strategies
8 Jul 2011
Abstract excerpt
The myeloproliferative neoplasms (MPNs) are a group of clonal hematological malignancies characterized by a hypercellular bone marrow and a tendency to develop thrombotic complications and to evolve to myelofibrosis and acute leukemia. Unlike chronic myelogenous leukemia, where a single disease-initiating genetic event has been identified, a more complicated series of genetic mutations appear to be responsible...
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