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Dysregulation and overexpression of HMGA2 in myelofibrosis with myeloid metaplasia

10 Oct 2003

Abstract excerpt

Among cytogenetic studies of patients affected with myelofibrosis with myeloid metaplasia (MMM), a rare chronic myeloproliferative disorder, we found several reports of structural abnormalities of the long arm of chromosome 12. Two MMM patients had a balanced translocation involving 12q: t(4;12)(q32;q15) and t(5;12)(p14;q15), respectively. FISH (fluorescence in situ hybridization) analysis showed that BAC...

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PMID: 14603445
DOI: 10.1002/gcc.10297

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