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Article

Aberrant let7a/HMGA2 signaling activity with unique clinical phenotype in JAK2-mutated myeloproliferative neoplasms.

Haematologica - 1 Mar 2017

Chen Chih-Cheng, You Jie-Yu, Lung Jrhau, Huang Cih-En, Chen Yi-Yang, Leu Yu-Wei, Ho Hsing-Ying, Li Chian-Pei, Lu Chang-Hsien, Lee Kuan-Der, Hsu Chia-Chen, Gau Jyh-Pyng

Abstract excerpt

High mobility group AT-hook 2 (HMGA2) is an architectural transcription factor that is negatively regulated by let-7 microRNA through binding to it's 3'-untranslated region. Transgenic mice expressing Hmga2 with a truncation of its 3'-untranslated region has been shown to exhibit a myeloproliferative phenotype. To decipher the let-7-HMGA2 axis in myeloproliferative neoplasms, we employed an in vitro model...

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Topics

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Share to Chromosomes, Human, Pair 12
Share to Gene Silencing

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to HMGA2 Protein

Share to Hydroxyurea

Share to Janus Kinase 2

Share to Myeloproliferative Disorders

Share to STAT Transcription Factors

Share to Translocation, Genetic

Source

Open in PubMed Open full text

Identifiers

PMID: 28057739
DOI: 10.3324/haematol.2016.154385
PMCID: PMC5394969

Genes

HMGA2
JAK2
CALR
MPL

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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