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Article

The role of HMGA2 in the proliferation and expansion of a hematopoietic cell in myeloproliferative neoplasms.

Fukushima journal of medical science - 1 Jan 2012

Ikeda Kazuhiko, Ogawa Kazuei, Takeishi Yasuchika

Abstract excerpt

Philadelphia chromosome-negative myeloproliferative neoplasms (MPN), which include polycythemia vera, essential thrombocythemia, and primary myelofibrosis, are characterized by clonal proliferative hematopoiesis with increased blood cell count. Clonal expansion mechanisms in MPN and related disorders such as myelodysplastic syndromes (MDS) remain to be elucidated. Although mutations in the JAK2 gene lead to a...

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Source

Identifiers

PMID: 23237864
DOI: 10.5387/fms.58.91

Genes

HMGA2
JAK2
TET2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

The role of HMGA2 in the proliferation and expansion of a hematopoietic cell in myeloproliferative neoplasms.PMID 23237864Read ↗

Hmga2 collaborates with JAK2V617F in the development of myeloproliferative neoplasmsSemantic proximity Read ↗

Aberrant let7a/HMGA2 signaling activity with unique clinical phenotype in JAK2-mutated myeloproliferative neoplasms.Semantic proximity Read ↗

HMGA1 chromatin regulators induce transcriptional networks involved in GATA2 and proliferation during MPN progressionSemantic proximity Read ↗

HMGA2 overexpression with specific chromosomal abnormalities predominate in CALR and ASXL1 mutated myelofibrosis.Semantic proximity Read ↗

Dysregulation of the <i><scp>MIRLET</scp>7</i>/<i><scp>HMGA</scp>2</i> axis with methylation of the <i><scp>CDKN</scp>2A</i> promoter in myeloproliferative neoplasmsSemantic proximity Read ↗

Dysregulation and overexpression of HMGA2 in myelofibrosis with myeloid metaplasiaSemantic proximity Read ↗

3′UTR-truncated Hmga2 cDNA causes MPN-like hematopoiesis by conferring a clonal growth advantage at the level of HSC in miceSemantic proximity Read ↗

[Pathogenic role of insufficiency of polycomb repressive complex in primary myelofibrosis].Semantic proximity Read ↗

Concurrent loss of Ezh2 and Tet2 cooperates in the pathogenesis of myelodysplastic disorders.Semantic proximity Read ↗

The loss of Ezh2 drives the pathogenesis of myelofibrosis and sensitizes tumor-initiating cells to bromodomain inhibitionSemantic proximity Read ↗

Roles of HMGA proteins in cancer.Semantic proximity Read ↗

Loss of <i>Ezh2</i> synergizes with <i>JAK2</i> -V617F in initiating myeloproliferative neoplasms and promoting myelofibrosisSemantic proximity Read ↗

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