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Article

Hmga2 collaborates with JAK2V617F in the development of myeloproliferative neoplasms

14 Jun 2017

Abstract excerpt

Key Points In patients with MPNs, repression of MIRlet-7 and mutations in the polycomb genes EZH2 and ASXL1 correlate with HMGA2 overexpression. Hmga2 overexpression collaborates with JAK2V617F to promote lethal MPN in mice, highlighting the crucial role of Hmga2.

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Identifiers

PMID: 29296743
DOI: 10.1182/bloodadvances.2017004457

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