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Dysregulation of the <i><scp>MIRLET</scp>7</i>/<i><scp>HMGA</scp>2</i> axis with methylation of the <i><scp>CDKN</scp>2A</i> promoter in myeloproliferative neoplasms

19 Sept 2014

Abstract excerpt

Overexpression of high mobility group AT-hook 2 (Hmga2), which is negatively regulated by MIRLET7 micro RNAs through 3'-untranslated region (3'UTR), causes proliferative haematopoiesis mimicking myeloproliferative neoplasms (MPNs) and contributes to progression of myelofibrosis in mice. Thus, we investigated HMGA2 mRNA expression in 66 patients with MPNs including 23 polycythaemia vera (PV), 33 essential...

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PMID: 25236537
DOI: 10.1111/bjh.13129

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