Article

Analysis of Circulating Protein Aggregates Reveals Pathological Hallmarks of Amyotrophic Lateral Sclerosis

2020-09-18

Abstract excerpt

<title>Abstract</title> <p><bold>Background:</bold> plasma proteins composition reflects the inflammatory and metabolic state of an organism and can be predictive of system-level and organ-specific pathologies. Circulating protein aggregates (CPA) are enriched with heavy chain neurofilaments (NfH), axonal proteins involved in brain protein aggregates (BPA) formation and recently identified as biomarkers of the fa...

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Literature Corpus work: 5dc9c1ee-d6dd-595e-9842-7df8db4ebcb1
DOI: 10.21203/rs.3.rs-71596/v1

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