Article

GFAP Degradation in TBI: Linking Novel Modified Products to Astrocyte Pathology and Patient Outcome

2025-08-01

Abstract excerpt

<h4>ABSTRACT</h4> Glial fibrillary acidic protein (GFAP) is a significant clinical biomarker of traumatic brain injury (TBI), yet understanding the nature, timing, and impact of its degraded and modified products would inform clinical utility. We report novel GFAP breakdown products (BDPs) and post-translational modifications (PTMs) that are unique to TBI including fragment- and patient-specific citrullination si...

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Literature Corpus work: 29ca19f0-0f31-5e7a-bb84-86e6c03c0979
DOI: 10.1101/2025.08.01.668181

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