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Article

Aberrant Protein Deposition and Neurological Disease

1 Dec 1999

Abstract excerpt

The association of protein deposits with neurodegeneration has become a consistent finding in a large group of etiologically diverse diseases (1, 2) (Table I). The protein deposits are generally dense fibrillar structures containing a high percentage of b-pleated sheet secondary structure and can be located in various cellular compart-ments as well as extracellularly. Moreover, the deposits are gener-ally...

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PMID: 10608801
DOI: 10.1074/jbc.274.53.37507

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