Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Islands of genomic stability in the face of genetically unstable metastatic cancer.

PloS one - 1 Jan 2024

Bowland Kirsten, Lai Jiaying, Skaist Alyza, Zhang Yan, Teh Selina Shiqing K, Roberts Nicholas J, Thompson Elizabeth, Wheelan Sarah J, Hruban Ralph H, Karchin Rachel, Bailey Matthew H, Iacobuzio-Donahue Christine A, Eshleman James R

Abstract excerpt

INTRODUCTION: Metastatic cancer affects millions of people worldwide annually and is the leading cause of cancer-related deaths. Most patients with metastatic disease are not eligible for surgical resection, and current therapeutic regimens have varying success rates, some with 5-year survival rates below 5%. Here, we test the hypothesis that metastatic cancer can be genetically targeted by exploiting single base...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Carcinoma, Pancreatic Ductal
Share to CRISPR-Cas Systems

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to PAM gene

Share to Genomic Instability

Share to Mutation

Share to Neoplasm Metastasis

Share to Pancreatic Neoplasms

Share to Whole Genome Sequencing

Source

Open in PubMed Open full text

Identifiers

PMID: 39700179
DOI: 10.1371/journal.pone.0298490
PMCID: PMC11658618

Genes

PAM

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Islands of genomic stability in the face of genetically unstable metastatic cancer.PMID 39700179Read ↗

Islands of genomic stability in the face of genetically unstable metastatic cancerSemantic proximity Read ↗

A system for detecting high impact-low frequency mutations in primary tumors and metastases.Semantic proximity Read ↗

Distant metastasis occurs late during the genetic evolution of pancreatic cancer.Semantic proximity Read ↗

CRISPR-Cas9 for selective targeting of somatic mutations in pancreatic cancersSemantic proximity Read ↗

Insertional mutagenesis defines drivers and evolutionary relationships in pancreatic cancer metastasisSemantic proximity Read ↗

Limited heterogeneity of known driver gene mutations among the metastases of individual patients with pancreatic cancer.Semantic proximity Read ↗

Distinctive Spatiotemporal Stability of Somatic Mutations in Metastasized Microsatellite-stable Colorectal Cancer.Semantic proximity Read ↗

Hypoxia-induced metastatic heterogeneity in pancreatic cancerSemantic proximity Read ↗

Sleeping Beauty mutagenesis reveals cooperating mutations and pathways in pancreatic adenocarcinoma.Semantic proximity Read ↗

Whole Exome Sequencing of Rapid Autopsy Tumors and Xenograft Models Reveals Possible Driver Mutations Underlying Tumor ProgressionSemantic proximity Read ↗

Comparative lesion sequencing provides insights into tumor evolution.Semantic proximity Read ↗

Targeted Sequencing of Pancreatic Adenocarcinomas from Patients with Metachronous Pulmonary Metastases.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.