Article
Distant metastasis occurs late during the genetic evolution of pancreatic cancer.
Nature - 28 Oct 2010
Yachida Shinichi, Jones Siân, Bozic Ivana, Antal Tibor, Leary Rebecca, Fu Baojin, Kamiyama Mihoko, Hruban Ralph H, Eshleman James R, Nowak Martin A, Velculescu Victor E, Kinzler Kenneth W, Vogelstein Bert, Iacobuzio-Donahue Christine A
Abstract excerpt
Metastasis, the dissemination and growth of neoplastic cells in an organ distinct from that in which they originated, is the most common cause of death in cancer patients. This is particularly true for pancreatic cancers, where most patients are diagnosed with metastatic disease and few show a sustained response to chemotherapy or radiation therapy. Whether the dismal prognosis of patients with pancreatic cancer...
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