Article
Limited heterogeneity of known driver gene mutations among the metastases of individual patients with pancreatic cancer.
Nature genetics - 1 Mar 2017
Makohon-Moore Alvin P, Zhang Ming, Reiter Johannes G, Bozic Ivana, Allen Benjamin, Kundu Deepanjan, Chatterjee Krishnendu, Wong Fay, Jiao Yuchen, Kohutek Zachary A, Hong Jungeui, Attiyeh Marc, Javier Breanna, Wood Laura D, Hruban Ralph H, Nowak Martin A, Papadopoulos Nickolas, Kinzler Kenneth W, Vogelstein Bert, Iacobuzio-Donahue Christine A
Abstract excerpt
The extent of heterogeneity among driver gene mutations present in naturally occurring metastases-that is, treatment-naive metastatic disease-is largely unknown. To address this issue, we carried out 60× whole-genome sequencing of 26 metastases from four patients with pancreatic cancer. We found that identical mutations in known driver genes were present in every metastatic lesion for each patient studied....
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