Insertional mutagenesis defines drivers and evolutionary relationships in pancreatic cancer metastasis

Abstract excerpt

<h4>ABSTRACT</h4> Metastasis is a defining feature of pancreatic cancer, impacting patient quality of life and therapeutic outcomes. While recurrent mutations in KRAS and TP53 play important roles in primary tumor development and persist in metastases, the contributions of other genes to the metastatic process is understudied. Here, we define a network of metastasis-promoting genes and uncover positively select...

Topics

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• Catenins
• Delta Catenin
• Genes, ras
• GTP-Binding Protein alpha Subunits
• GTP-Binding Protein alpha Subunits, Gq-G11
• Mice, 129 Strain
• Pancreas
• Pancreatic Neoplasms

Identifiers and source

Literature Corpus work

97fecefb-b320-5cb5-9a4e-cf8d8f1a21bc

DOI

10.1101/2020.09.28.317701