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Targeted Sequencing of Pancreatic Adenocarcinomas from Patients with Metachronous Pulmonary Metastases.

Genes - 24 Nov 2020

Hlavac Viktor, Mohelnikova-Duchonova Beatrice, Lovecek Martin, Ehrmann Jiri, Brynychova Veronika, Kolarova Katerina, Soucek Pavel

Abstract excerpt

Mutation spectra of 250 cancer driver, druggable, and actionable genes were analyzed in surgically resected pancreatic ductal adenocarcinoma (PDAC) patients who developed metachronous pulmonary metastases. Targeted sequencing was performed in DNA from blood and archival samples of 15 primary tumors and three paired metastases. Results were complemented with the determination of G12V mutation in KRAS by droplet...

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PMID: 33255265
DOI: 10.3390/genes11121391
PMCID: PMC7760784

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