Article
Sleeping Beauty mutagenesis reveals cooperating mutations and pathways in pancreatic adenocarcinoma.
Proceedings of the National Academy of Sciences of the United States of America - 17 Apr 2012
Mann Karen M, Ward Jerrold M, Yew Christopher Chin Kuan, Kovochich Anne, Dawson David W, Black Michael A, Brett Benjamin T, Sheetz Todd E, Dupuy Adam J, Chang David K, Biankin Andrew V, Waddell Nicola, Kassahn Karin S, Grimmond Sean M, Rust Alistair G, Adams David J, Jenkins Nancy A, Copeland Neal G
Abstract excerpt
Pancreatic cancer is one of the most deadly cancers affecting the Western world. Because the disease is highly metastatic and difficult to diagnosis until late stages, the 5-y survival rate is around 5%. The identification of molecular cancer drivers is critical for furthering our understanding of the disease and development of improved diagnostic tools and therapeutics. We have conducted a mutagenic screen using...
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