Article
Detection of Streptococcus pyogenes M1UK in Australia and characterization of the mutation driving enhanced expression of superantigen SpeA.
Nature communications - 24 Feb 2023
Davies Mark R, Keller Nadia, Brouwer Stephan, Jespersen Magnus G, Cork Amanda J, Hayes Andrew J, Pitt Miranda E, De Oliveira David M P, Harbison-Price Nichaela, Bertolla Olivia M, Mediati Daniel G, Curren Bodie F, Taiaroa George, Lacey Jake A, Smith Helen V, Fang Ning-Xia, Coin Lachlan J M, Stevens Kerrie, Tong Steven Y C, Sanderson-Smith Martina, Tree Jai J, Irwin Adam D, Grimwood Keith, Howden Benjamin P, Jennison Amy V, Walker Mark J
Abstract excerpt
A new variant of Streptococcus pyogenes serotype M1 (designated 'M1UK') has been reported in the United Kingdom, linked with seasonal scarlet fever surges, marked increase in invasive infections, and exhibiting enhanced expression of the superantigen SpeA. The progenitor S. pyogenes 'M1global' and M1UK clones can be differentiated by 27 SNPs and 4 indels, yet the mechanism for speA upregulation is unknown. Here...
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