Rapid expansion and international spread of M1UK in the post-pandemic UK upsurge of Streptococcus pyogenes.

doi:10.1038/s41467-024-47929-7

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Article

Rapid expansion and international spread of M1UK in the post-pandemic UK upsurge of Streptococcus pyogenes.

Nature communications - 10 May 2024

Vieira Ana, Wan Yu, Ryan Yan, Li Ho Kwong, Guy Rebecca L, Papangeli Maria, Huse Kristin K, Reeves Lucy C, Soo Valerie W C, Daniel Roger, Harley Alessandra, Broughton Karen, Dhami Chenchal, Ganner Mark, Ganner Marjorie A, Mumin Zaynab, Razaei Maryam, Rundberg Emma, Mammadov Rufat, Mills Ewurabena A, Sgro Vincenzo, Mok Kai Yi, Didelot Xavier, Croucher Nicholas J, Jauneikaite Elita, Lamagni Theresa, Brown Colin S, Coelho Juliana, Sriskandan Shiranee

Abstract excerpt

The UK observed a marked increase in scarlet fever and invasive group A streptococcal infection in 2022 with severe outcomes in children and similar trends worldwide. Here we report lineage M1UK to be the dominant source of invasive infections in this upsurge. Compared with ancestral M1global strains, invasive M1UK strains exhibit reduced genomic diversity and fewer mutations in two-component regulator genes...

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PMID: 38729927
DOI: 10.1038/s41467-024-47929-7
PMCID: PMC11087535

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