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Article

Pleiotropic Associations with Alzheimer's Disease and Physical Activity: Sex Differences and the Effects of Environment.

International journal of molecular sciences - 22 Nov 2024

Loika Yury, Loiko Elena, Culminskaya Irina, Kulminski Alexander M

Abstract excerpt

Physical activity (PA) is a modifiable factor in mitigating/preventing Alzheimer's disease (AD). It is crucial to identify the conditions under which PA's effects on AD risk would be beneficial. This study aims to gain insights into pleiotropic predisposition to AD and PA within and across sexes and environmental effects. We performed a genome-wide association study (GWAS) of pleiotropic AD-PA associations in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 39684283
DOI: 10.3390/ijms252312571
PMCID: PMC11641332

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