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Article

Physical activity and Alzheimer's disease risk across genetic susceptibility: a prospective UK Biobank study using accelerometer data.

Journal of neurology - 2 Dec 2025

Na Seunghee, Muir Kenneth, Lophatananon Artitaya, Huang Yicong, Lee Jongin

Abstract excerpt

OBJECTIVE: Physical activity (PA) has been associated with reduced Alzheimer's disease (AD) risk, but whether protective effects vary across genetic risk levels remains unclear. Previous studies were limited by self-reported PA measures and simplified genetic models. In this study, we aimed to examine the association between accelerometer-measured physical activity and the risk of incident AD in a large...

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Identifiers

PMID: 41329349
DOI: 10.1007/s00415-025-13524-z
PMCID: PMC12672744

Genes

APOE

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