Article
A cost-effective, high-throughput, highly accurate genotyping method for outbred populations.
G3 (Bethesda, Md.) - 5 Feb 2025
Chen Denghui, Chitre Apurva S, Nguyen Khai-Minh H, Cohen Katerina A, Peng Beverly F, Ziegler Kendra S, Okamoto Faith, Lin Bonnie, Johnson Benjamin B, Sanches Thiago M, Cheng Riyan, Polesskaya Oksana, Palmer Abraham A
Abstract excerpt
Affordable sequencing and genotyping methods are essential for large-scale genome-wide association studies. While genotyping microarrays and reference panels for imputation are available for human subjects, nonhuman model systems often lack such options. Our lab previously demonstrated an efficient and cost-effective method to genotype heterogeneous stock rats using double-digest genotyping by sequencing....
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