A Cost-effective, High-throughput, Highly Accurate Genotyping Method for Outbred Populations

Abstract excerpt

Affordable sequencing and genotyping methods are essential for large scale genome-wide association studies. While genotyping microarrays and reference panels for imputation are available for human subjects, non-human model systems often lack such options. Our lab previously demonstrated an efficient and cost-effective method to genotype heterogeneous stock rats using double-digest genotyping-by-sequencing. However...

Topics

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• Cost-Benefit Analysis
• Genome-Wide Association Study
• Genotype
• Genotyping Techniques
• High-Throughput Nucleotide Sequencing
• Polymorphism, Single Nucleotide
• Rats
• Whole Genome Sequencing

Identifiers and source

Literature Corpus work

598078fb-a271-584a-8344-2065d49b4ce0

DOI

10.1101/2024.07.17.603984