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Article

LRRK2 mutation contributes to decreased free water in the nucleus basalis of Meynert in manifest and premanifest Parkinson's disease.

Journal of neurology - 12 Dec 2024

Wang Chao, Wang Shuyue, Zhou Cheng, Wu Chenqing, Yang Siyu, Xu Xiaojun, Zhang Minming, Huang Peiyu

Abstract excerpt

BACKGROUND: Free-water imaging can predict and monitor dopamine system degeneration in patients with Parkinson's disease (PD). However, brain cholinergic function has not been investigated to date in LRRK2 mutation carriers with or without PD using free-water imaging. OBJECTIVES: To investigate the effect of LRRK2 mutations on the cholinergic system in manifest and premanifest stages of PD using free-water...

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PMID: 39666095
DOI: 10.1007/s00415-024-12811-5

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