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Free-Water Imaging of the Substantia Nigra in GBA Pathogenic Variant Carriers.

Movement disorders : official journal of the Movement Disorder Society - 1 May 2023

Zhang Dongling, Shi Yuting, Yao Junye, Zhou Liche, Wei Hongjiang, Liu Jun, Tong Qiqi, Ma Lingyan, He Hongjian, Wu Tao

Abstract excerpt

BACKGROUND: Pathogenic variants in the glucocerebrosidase gene (GBA) have been identified as the most common genetic risk factor for Parkinson's disease (PD). However, the features of substantia nigra damage in GBA pathogenic variant carriers remain unclear. OBJECTIVE: We aimed to evaluate the microstructural changes in the substantia nigra in non-manifesting GBA pathogenic variant carriers (GBA-NMC) and PD...

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PMID: 36797645
DOI: 10.1002/mds.29356

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